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When the journal was founded in 1964, one of the journal goals was to capture the rich heterocyclic chemistry that was being conducted by synthetic organic and medicinal chemists around the world. In many cases this chemistry was not being published in the more general journals of that time. The journal has been very successful in attracting authors to submit manuscripts on the subject of heterocyclic chemistry and a wealth of chemical information has been captured that would otherwise never have been recorded. It is ironic that again the field finds itself in a position where only a small fraction of the heterocyclic compounds produced are able to be reported in the literature.