The Chemical Probes Portal seeks to increase the reproducibility of biomedical research using chemical probes through community curation and communication. Each year, millions of public and private research dollars are applied to the development and/or application of chemical tools, termed chemical probes, which can be powerful reagents that enable the drug discovery and development efforts that bring new medicines to patients. Unfortunately, much of this money is wasted, as scientists either opt to use inferior quality chemical probes or apply high quality probes in inappropriate or invalid ways.